Ongoing Investigator-Initiated Studies

Ongoing Investigator-Initiated Studies

There are a number of investigator-initiated studies related to Mallinckrodt products in varying stages of completion. The following studies are listed on www.clinicaltrials.gov. Click on the links provided below to learn more.

H.P. Acthar Gel

A Single Site, Investigator Initiated Open Label Trial of Acthar in Subjects with Moderately to Severely Active Psoriatic Arthritis

ACTH as Treatment for Intractable Chronic Migraine

ACTH for Acute Treatment if Rheumatoid Arthritis Patients with Inadequate Response to Methotrexate

ACTH for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome in Children

Acthar as Adjunctive Therapy in Patients with Rheumatoid Arthritis who Have Failed at Least Three Biologic Therapies with Different Modes of Action

Acthar as Rescue Therapy for Transplant Glomerulopathy (TG) in Kidney Transplant Recipients

Acthar Dermatomyositis and Polymyosities Treatment (ADAPT Registry)

Acthar Effects on Myelination in Multiple Sclerosis Patients

Acthar in the Treatment of Lupus Nephritis

Addition of Acthar to Treatment Regimen of Patients with Rheumatoid Arthritis Inadequately Controlled with Biologic Disease-Modifying Agents

An Open-Label Pilot Study of ACTH in the Treatment of IgA Nephropathy at High Risk of Progression

An Open-Label Randomized Phase IV Study of the Safety and Efficacy of Acthar in Patients with Membranous Lupus Nephritis

Analysis of Relapse in Multiple Sclerosis

Clinical Biomarkers of Disease Activity and Treatment Response in Patients with CNS Sarcoidosis Treated with ACTH Gel

Cognitive Relapse in Multiple Sclerosis

Comparison of Monthly Pulse ACTH Therapy with Methylprednisolone for Long-Term Treatment of Multiple Sclerosis (MS) as an Add-on Therapy to Beta-interferons

Defining the Functional and Neuro-protective Potential of Acthar in Acute Optic Neuritis

Early Treatment of Infants at High Risk of Developing West Syndrome with Low-dose Adrenocorticotropin Hormone (ACTH)

Effect of ACTH on Measures of Fatigue in Patients with Relapsing Multiple Sclerosis

Efficacy and Safety of Acthar for the Treatment of Refractory Cutaneous Manifestations of Dermatomyositis

Impact of Acthar on Proteinuria and Disease Progression in IgA Nephropathy Patients with Nephrotic Range Proteinuria

Multiple Sclerosis Relapse Patients Who Failed Recovery After High Dose IV Methylprednisolone

Neuroinflammation in Children with Infantile Spasms Measured with 11C-PK In11195 PET Response to ACTH

Ocular Sarcoidosis: Open Label Trial of Acthar Gel

Open Label Proof of Concept Study to Evaluate Efficacy and Safety of ACTH Gel in Refractory DM/PM

Open Label Study to Evaluate Efficacy and Safety of Short-term Adjunctive Adrenocorticotropic Hormone (ACTH) Gel Therapy in Rheumatoid Arthritis

Phase 4 Trial of Neuroprotection with ACTH in Acute Optic Neuritis

Pilot Trial of ACTH 14 Days vs 5 Days Multiple Sclerosis Relapse

Prospective Open Label Study of Acthar in Patients with Active Anterior Uveitis Who are Not Controlled with, or Intolerant to, Corticosteroids

Pulmonary Sarcoidosis Open Label Trial of Acthar Gel

Safety and Efficacy of Acthar Gel in Outpatient Dialysis Population

The Effect of ACTH with Methotrexate in Newly Diagnosed Rheumatoid Arthritis Patients from a Clinical and Structural Perspective as Measured by a CDAI Score

Tolerability of ACTH for Multiple Sclerosis Relapses

Treatment of Aggressive Forms of Multiple Sclerosis with Pulsed ACTH

Whole Exome Sequencing and ACTH Responsiveness in Infantile Spasms

INOMAX

Dynamic Assessment Of Right Ventricular Function With Inhaled Nitric Oxide During Cardiac MRI

Effect Of Early Ino On Oxidative Stress, Vascular Tone, And Inflammation In Term And Late Preterm Infants With Hypoxic Respiratory Failure

Efficacy Of Nitric Oxide Administration In Attenuating Ischemia/Reperfusion Injury During Neonatal Cardiopulmonary Bypass

Inhaled Nitric Oxide And Neuroprotection In Premature Infants

Inhaled NO In Pulmonary Embolism, A Randomized, Double Blind, Placebo Controlled Study

Investigation Of The Effect Of Nitric Oxide On Ischemia Reperfusion Injury During Extended Donor Criteria Liver Transplantation

Potential Use Of Inhaled Nitric Oxide (Ino) As An Adjunct To Neonatal Resuscitation Protocol

OFIRMEV

Analgesia Efficacy of Repeated Doses of Intravenous Acetaminophen (Paracetamol) in the Pediatric Spinal Fusion Population

Analgesic and Opioid-sparring Effects of IV APAP During Craniotomy

Dexmedetomidine and IV acetaminophen For The Prevention Of Postoperative Delirium Following Cardiac Surgery In Adult Patients 60 Years Of Age And Older

Effect of Intravenous Acetaminophen on Postoperative Opioid-related Complications

Pharmacoeconomics and Related Patient Outcomes of Multi-dose Intravenous Acetaminophen (OFIRMEV) in Patients Undergoing Robotic-assisted Laparoscopic Prostatectomy

Prospective, Double blind, Placebo control, Study of Acetaminophen IV on Hospital Length Of Stay in Morbidly Obese Individuals Undergoing Elective Laparoscopic Sleeve Gastrectomy